2025
Ong JN, Grindel BJ, Rankin SA, Naylon SH, Srinivasamani A, Trusz GJ, Liang X, Uddin MN, Fuller L, Curran M, Roche SP, Takahashi TT, Roberts RW, Millward SW. (2025). Using extension‐based mRNA display to design antibody‐like proteinogenic peptides for human PD‐L1. Protein Sci., 34(9), e70268. doi: 10.1002/pro.70268
2022
Grindel BJ, Engel BJ, Ong JN, Srinivasamani A, Liang X, Zacharias NM, Bast RC, Curran MA, Takahashi TT, Roberts RW, Millward SW. (2022). Directed Evolution of PD-L1-Targeted Affibodies by mRNA Display. ACS Chem. Biol., 17(6), 1543-1555. doi: 10.1021/acschembio.2c00218
Lin WZS, Evenson WE, Bostic WKV, Roberts RW, Malmstadt N. (2022). Compatibility of popular three-dimensional printed microfluidics materials with in vitro enzymatic reactions. ACS Appl. Bio Mater., 5(2), 818-824. doi: 10.1021/acsabm.1c01180
2021
Kamalinia G, Grindel BJ, Takahashi TT, Millward SW, Roberts RW. (2021). Directing evolution of novel ligands by mRNA display. Chem. Soc. Rev., 50(16), 9055-9103. doi: 10.1039/D1CS00160D
2020
Evenson WE, Lin WZS, Pang K, Czaja A, Jalali-Yazdi F, Takahashi TT, Malmstadt N, Roberts RW. (2020). Enabling Flow-Based Kinetic Off-Rate Selections Using a Microfluidic Enrichment Device. Anal. Chem., 92(15), 10218-10222. doi: 10.1021/acs.analchem.0c01867.
Kamalinia G, Engel BJ, Srinivasamani A, Grindel BJ, Ong JN, Curran MA, Takahashi TT, Millward SW, Roberts RW. (2020). mRNA display discovery of a novel programmed death ligand 1 (PD-L1) binding peptide (a peptide ligand for PD-L1). ACS Chem. Biol., 15(6), 1630-1641. doi: 10.1021/acschembio.0c00264.
Lin WZS, Evenson WE, Pang K, Roberts RW, Malmstadt N. (2020). Preparation of Peptides with High Affinity to Cancer Targets in mRNA Display via Continuous-Flow Microfluidics. Biophys. J., 118(3), 152a.
2019
Ludwicki MB, Li J, Stephens EA, Roberts RW, Koise S, Hammon PT, DeLisa MP. (2019). Broad-spectrum proteome editing with an engineered bacterial ubiquitin ligase mimic. ACS Cent. Sci., 5(5), 852-866. doi: 10.1021/acscentsci.9b00127
2018
Nichols AL, Noridomi K, Hughes CR, Jalali-Yazdi F, Eaton JB, Lai LH, Advani G, Lukas RJ, Lester HA, Chem L, Roberts RW. (2018). α1-FANGs: Protein Ligands Selective for the α-Bungarotoxin Site of the α1-Nicotinic Acetylcholine Receptor. ACS Chem. Biol., 13, 2568–2576. doi: 10.1021/acschembio.8b00513
2017
Cetin M, Gross GG, Evenson WE, Jalali-Yazdi F, Takahashi TT, Arnold D, Roberts RW. (2017). RasIns: Genetically Encoded Intrabodies of Activated Ras Proteins. J. Mol. Biol., 429, 562. doi: 10.1016/j.jmb.2016.11.008
2016
Jalali-Yazdi, F., Lai L.H.., Takahashi, T.T., Roberts, R.W. (2016). High-Throughput Measurement of Binding Kinetics by mRNA Display and Next-Generation Sequencing. Angewandte Chemie International Edition, 55(12), 4007-4010. doi: 10.1002/anie.201600077
2015
Jalali-Yazdi, F., Takahashi, T.T., Roberts, R.W. (2015). General, Label-Free Method for Determining Kd and Ligand Concentration Simultaneously. Analytical Chemistry, 87(23), 11755-11762. doi: 10.1021/acs.analchem.5b03069
2014
Jalali-Yazdi, F., Corbin, J.M., Takahashi, T.T., Roberts, R.W. (2014). Robust, Quantitative Analysis of Proteins using Peptide Immunoreagents, in Vitro Translation, and an Ultrasensitive Acoustic Resonant Sensor. Analytical Chemistry, 86(10), 4715-4722. doi: 10.1021/ac500084d
Howell, S.M., Fiacco, S.V., Takahashi, T.T., Jalali-Yazdi, F., Millward, S.W., Hu, B., Wang, P., Roberts, R.W. (2014). Serum Stable Natural Peptides Designed by mRNA Display. Scientific Reports, 4(1), 6008.doi: 10.1038/srep06008
2013
Xiao, L., Hung, K.-C., Takahashi, T.T., Joo, K.-I., Lim, M., Roberts, R.W., Wang, P. (2013). Antibody-Mimetic Ligand Selected by mRNA Display Targets DC-SIGN for Dendritic Cell-Directed Antigen Delivery. ACS Chem. Bio., 8(5), 967-977. doi: 10.1021/cb300680c
Mora, R.J., Roberts, R.W., Arnold, D.B. (2013). Recombinant Probes Reveal Dynamic Localization of CaMKII alpha within Somata of Cortical Neurons. Journal of Neuroscience 33(36), 14579-14590. doi: 10.1523/JNEUROSCI.2108-13.2013
Gross, G.G., Junge, J.A., Mora, R.J., Kwon, H.-B., Olson, C.A., Takahashi, T.T., Liman, E.R., Ellis-Davies, G.C.R., McGee, A.W., Sabatini, B.L., Roberts, R.W., Arnold, D.B. (2013). Recombinant Probes for Visualizing Endogenous Synaptic Proteins in Living Neurons. Neuron, 78(6), 971-985. doi: 10.1016/j.neuron.2013.04.017
2012
Olson, C.A., Nie, J., Diep, J., Al-Shyoukh, I., Takahashi, T.T., Al-Mawsawi, L.Q., Bolin, J.M., Elwell, A.L., Swanson, S., Stewart, R., Thomson, J.A., Soh, H.T., Roberts, R.W., Sun, R. (2012). Single-Round, Multiplexed Antibody Mimetic Design through mRNA Display. Angewandte Chemie-International Edition, 51(50), 12449-12453. doi: 10.1002/anie.201207005
2011
Olson, C.A., Adams, J.D., Takahashi, T.T., Qi, H., Howell, S.M., Wu, T.-T., Roberts, R.W., Sun, R., Soh, H.T. (2011). Rapid mRNA-Display Selection of an IL-6 Inhibitor Using Continuous-Flow Magnetic Separation. Angewandte Chemie-International Edition, 50(36), 8295-8298. doi: 10.1002/anie.201101149
2010
Qi, X., Xia, T., Roberts, R.W. (2010). Acridine-N Peptide Conjugates Display Enhanced Affinity and Specificity for boxB RNA Targets. Biochemistry, 49, 5782-5789. doi: 10.1021/bi100634h
Ishikawa, F.N., Curreli, M., Olson, C.A., Liao, H.-I., Sun, R., Roberts, R.W., Cote, R.J., Thompson, M.E., Zhou, C. (2010). Importance of Controlling Nanotube Density for Highly Sensitive and Reliable Biosensors Functional in Physiological Conditions. ACS Nano, 4(11), 6914-6922. doi: 10.1021/nn101198u
2009
Liao, H.-I., Olson, C.A., Hwang, S., Deng, H., Wong, E., Baric, R.S., Roberts, R.W., Sun, R. (2009). mRNA Display Design of Fibronectin-based Intrabodies That Detect and Inhibit Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein. Journal of Biological Chemistry, 284(26), 17512-17520. doi: 10.1074/jbc.M901547200
Ja, W.W., Carvalho, G.B., Madrigal, M., Roberts, R.W., Benzer, S. (2009). The Drosophila G protein-coupled receptor, Methuselah, exhibits a promiscuous response to peptides. Protein Science, 18(11), 2203-2208. doi: 10.1002/pro.221
Ishikawa, F.N., Chang, H.-K., Curreli, M., Liao, H.-I., Olson, C.A., Chen, P.-C., Zhang, R., Roberts, R.W., Sun, R., Cote, R.J., Thompson, M.E., Zhou, C. (2009). Label-Free, Electrical Detection of the SARS Virus N-Protein with Nanowire Biosensors Utilizing Antibody Mimics as Capture Probes. ACS Nano, 3(5), 1219-1224. doi: 10.1021/nn900086c
2008
Olson, C.A., Liao, H.-I., Sun, R., Roberts, R.W. (2008). mRNA display selection of a high-affinity, modification-specific phospho-I kappa B alpha-binding fibronectin. ACS Chem. Bio., 3(8), 480-485. doi: 10.1021/cb800069c
Fiacco, S.V., Roberts, R.W. (2008). N-Methyl Scanning Mutagenesis Generates Protease-Resistant G Protein Ligands with Improved Affinity and Selectivity. ChemBioChem: a European Journal of Chemical Biology, 9(14), 2200-2203. doi: 10.1002/cbic.200800208
Austin, R.J., Ja, W.W., Roberts, R.W. (2008). Evolution of class-specific peptides targeting a hot spot of the G alpha s subunit. Journal of Molecular Biology, 377(5), 1406-1418. doi: 10.1016/j.jmb.2008.01.032
2007
Olson, C.A., Roberts, R.W. (2007). Design, expression, and stability of a diverse protein library based on the human fibronectin type III domain. Protein Science, 16(3), 476-484. doi: 10.1110/ps.062498407
Millward, S.W., Fiacco, S., Austin, R.J., Roberts, R.W. (2007). Design of cyclic peptides that bind protein surfaces with antibody-like affinity. ACS Chem. Bio., 2(9), 625-634. doi: 10.1021/cb7001126
Ja, W.W., West, A.P., Jr., Delker, S.L., Bjorkman, P.J., Benzer, S., Roberts, R.W. (2007). Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor. Nature Chemical Biology, 3, 415-419. doi: 10.1038/nchembio.2007.2
2006
Ja, W.W., Wiser, O., Austin, R.J., Jan, L.Y., Roberts, R.W. (2006). Turning G proteins on and off using peptide ligands. ACS Chem. Bio., 1(9), 570-574. doi: 10.1021/cb600345k